Izzie and Rae were the very best of friends, and thanks to Rae's dad getting remarried, Izzie was able to meet Josh, Rae's new stepbrother. It was clear to Rae, and everyone else, that Josh and Izzie belonged together, but wild eyed Izzie wasn't able to admit it so easily. Rae really wanted her step-brother and her best friend to be together, but realizes that maybe it isn't in her step-brother's best interest to be with Izzie. Izzie's inability to commit breaks Josh's heart over and over again. How many times will Josh take her back before he decides that it's the Last Time?