Chucky - Chucky is bad.

Tiffany dies

Six years after the events of the third and fourth films, Glen, the kind and gentle son of Chucky and Tiffany, has a nightmare in which he brutally murders a little girl's parents. In reality, he is living a life of embarrassment and abuse as a ventriloquist's dummy from his own point of view. Desperate to know his parents, Glen tracks Chucky and Tiffany down to Hollywood, where they are first shown killing a man who is dressed as Santa Claus for a movie. Upon tracking down his mom and dad, who are now dummies in one of Jennifer Tilly's films, Glen uses a voodoo amulet to bring them back to life. When Chucky (voice of Brad Dourif) finds out that Glen is his child, he faints. However, Tiffany (voice of Jennifer Tilly) is delighted and hugs her child. Tiffany and Chucky argue over whether Glen is male or female, due to his lack of genitals (though he is clearly a male). Chucky decides to continue labeling him as a boy, while Tiffany labels him as a girl, calling him "Glenda".

When a puppeteer Tony Gardner (designer) begins taking Tiffany apart, she and Chucky decapitate him with a piano wire. Jennifer Tilly sees the beheaded body and calls the police. Chucky, Tiffany, and Glen ride with her home in a limousine. Glen, having witnessed his mom and dad kill the puppeteer, asks them why they murder others, as he feels that violence is bad. Tiffany and Chucky make an agreement to quit killing, although Chucky only pretends to agree, crossing his fingers behind his back hoping to get Tiffany to shut up.

Jennifer tries to get a role as the Virgin Mary in Redman's directorial debut, but after Redman says that Jennifer isn't right for the part, she invites him over to her house. Chucky and Tiffany make plans to transfer their souls into Redman and Jennifer. Jennifer and Redman start to make love, only for Tiffany to knock them out. While they are unconscious, Tiffany inseminates Jennifer with Chucky's semen. Chucky leaves and takes Glen with him. After driving Britney Spears' car off the road, killing her, they proceed to go to a photographer's darkroom. The photographer, Pete Peters (John Waters), had taken pictures of Tilly kissing Redman, and of Chucky masturbating. Glen tries to warn Peters that Chucky will kill him, only for Peters to bump into a shelf, causing a jar of acid to fall and accidentally kill him. Chucky, overjoyed, believes Glen did this on purpose and takes a picture to celebrate, much to Glen's and Tiffany's dismay.

Jennifer awakens the next morning, realizes that she is pregnant and claims that Redman is responsible, though he denies this. Angered, Tiffany kills Redman by gutting him. The next day, Jennifer is horrified to find herself with a fully pregnant belly. The voodoo magic that fuels the killer dolls has also accelerated the pregnancy. Jennifer is captured by Chucky. Her chauffeur Stan, serving as Chucky's replacement body due to Redman's death, is also captured. Jennifer's assistant Joan (Hannah Spearritt) tries to help her, but she is brutally killed by Tiffany when she is sprayed with fire. Chucky later reveals that he killed three people and hid them in a closet like Tiffany did to Redman trying to stop "Tiffany" from "crying" when he believed that she was crying for killing Joan. However, it turns that it was Glenda, Glen's twin sister whose soul shares Glen's body. Tiffany finds out about this and smacks Glenda to break Glen out of this.

Jennifer gives birth to twins, a boy and a girl, and it is then that Chucky has an epiphany. After years of being an infamous killer doll, Chucky finally accepts his circumstances. Disturbed, Tiffany rejects Chucky and resolves to take Glen with her. Chucky throws a knife at Jennifer, but Stan jumps in front and is stabbed in the chest, and he tells Tilly that he loves her before he dies. Before Glen can decide which baby to possess, the police arrive, forcing the dolls to flee. Jennifer is rushed to the hospital by the police, but she claims she wants to see her babies. Tiffany drugs Jennifer and begins to possess her, but Chucky breaks in and kills Tiffany with an axe. Before Tiffany dies, she tells Glen to not make the same mistakes his mom and dad have made. Glen, devastated by his mother's death, snaps and fights Chucky. Jennifer throws an axe to Glen. When Glen picks up the axe, he impales Chucky in the chest. At that time, Chucky thought he was fighting against Glenda, but Glen reveals that it was he, himself, doing this, as he dismembers him. Glen then asks Chucky if he is proud of him and Chucky congratulates Glen before being decapitated and killed by his son. Realizing what he has done, Glen suffers an emotional breakdown, and Jennifer comforts him.

Five years later, at Glen and Glenda's birthday party, a nanny quits her job because Jennifer's daughter Glenda scares her. Jennifer lets her quit, only to kill her when she turns away, and Jennifer's eyes glow green, revealing that Tiffany was successful in possessing Jennifer's body. Glen has taken the body of the son, and receives a strange, unnamed present. When he opens the present, he sees that it's Chucky's right arm; frightened, he urinates himself and turns around. Chucky's arm then grabs him and he begins screaming as the screen smash cuts to black; Chucky's evil laughter is heard.