Many years after the defeat of the worlds greatest threats of ghost. Egon Spengler fleds to Oklahoma to find a way to stop a long enemy to protect those he loves. There he moves to an old abandon houses where he will do his work. With Janine melnitz by his side to watch over him and he befriends and mentors a young woman named Casey Floyd who has an experience of abandonment. Egon learns the town had many secrets new allies and enemies come by. Egon had no choice but to teach Casey and her two new friends axel and Jesse how to be the new ghostbusters. This story is about family, friendship and love.