Stan: Pansexual
I think that if Wendy has taught Stan anything it would be that gender shouldn't matter.
Kyle: Straight or Bi but for sure demisexual
I think he could be straight because he hasn't really shown an interest in boys but I think he might later fall for Cartman or Stan time will tell. But to be honest I see Kyman to be more likely to be canon because it's fucked up, Cartman has a weird obsession with Kyle, Kyle recently has shown Cartman more affection lately. But that's just my opinion and as much as I am bias I'm not hating on Style, K2, etc.
Cartman: Bi with a preference of boys
He's only shown interest in two girls so he's not gay but he prefers boys. He sucked Butters dick and watched him put on a condom. All kyman moments. He jacked off Ben Affleck. Cupid me likes dick and he made out with a Justin Timberlake cutout.
Kenny: Pansexual
He doesn't really care who you are as long as you're a cool person. He typically goes for girls (Tammy and Kelly) and he showed Butters affection. And I want to get this off my chest Kenny is not a slut he is a pervert there is a difference in a fact innocent Kyle has had more flings than Kenny.
Butters: Pansexual Demisexual
He doesn't care as long as it's for love.
Craig: Bi
In Tweek x Craig he denies being gay but I'm sure if him and Tweek keep fake dating they will get a bond that becomes romantic
Tweek: Gay
He hasn't shown any interest in anyone but he stopped tweaking out when him and Craig got together so I think that says something.
Clyde: Bi with a preference of girls
I think he's into girls like a lot but if he has a strong enough connection with a boy he would date him.
Token: Straight
He hasn't shown any interest in any males but has dated Wendy and Nicole (I love Nicole, she's adorable)
Jimmy: Straight
He hasn't really shown any interest in boys but has had a girlfriend soooo.
Timmy: undecided
Wendy: Pansexual
It's Wendy
Bebe: Straight with a boner for Wendy
Bebe is straight but would go gay for Wendy