At the request of his older sister, student Hōtarō Oreki joins Kamiyama High School's Classic Literature Club to stop it from being abolished, joined by fellow members Eru Chitanda, Satoshi Fukube and Mayaka Ibara. The story is set in Kamiyama City, a fictional city in Gifu Prefecture that the author based on his real hometown of Takayama, also in Gifu. The fictional Kamiyama High School is based upon the real life Hida High School.
