Respected for his previous work, Doctor Julian Markus is tasked with curing one of humanity's biggest problems, Fear. Markus attempts to develop a serum to nullify Phobias but instead creates something that rivals fear itself. The serum will cause the subjects Phobia to invoke and become a nightmarish parasite called a Kindred; granting the subject abilities that relate to the Phobia. Markus' psychopathic tendencies pushes him to inject the serum through 7 patients' bloodstreams. However, the last patient, Isaac, wakes up prematurely during the operation. Markus tells the boy that the experiment is to test a hypothesis. The more the patients use their Kindreds the more it takes over, turning them into barbaric serial killers; Markus is quite sure this will be the case. Isaac goes in to utter despair knowing people like him will kill innocent people and desperately asks the Doctor if there is a way to stop it. Markus explains that the only way to stop this disaster from occurring is to hunt down the other patients and persuade them to stop using their Kindreds or kill them using your own Kindred. Will Isaac conquer his fear and save the other patients, or will his fear conquer him, forever.