18-year-old Macayla Rivers lives a very real and dangerous life. Her family comes from a long line of assassins and vampire slayers. Little did she know that she'd have to utilize both skills to survive. 6 years after the world has been taken over by vampires, Macayla and her girlfriend Flower, who's been turned into a vampire due to a pureblood named Mother Bathory, make it their mission to slaughter all the vampires they can, take back the world from the vampires once and for all and find a cure for Flower. Equipped with knowledge and weapons, Macayla and Flower embark on a journey to seek out Mother Bathory, the vampire of all vampires and the very first one to be precise, in New York City and kill her.