Samantha Winchester is an Omega who lives with her cruel Alpha father, and her older brother Dean. Because of her rank and the fact that her birth caused the death of her mother, John refuses to take care of her but favors his older son. The poor girl doesn't understand why, and grows up thinking Dean is her father, since he is the one that takes care of her. Eventually the neglect and favoritism becomes too much and Samantha runs away. While Dean does eventually find her, he quickly learns his sister has gotten herself in a lot of trouble. How will he help her?