Lady Tsunade is waaaaaay too old for starters, but I mainly avoid this ship because they're heterosexual characters... Tsunade is her mentor and Sakura the student, so they've spent x amount of time together which resulted in mutual respect and admiration between these two ladies.
Sakura doesn't "take after" Tsunade. She's just putting the lessons that nearly killed her to use.
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Kitty Reacts to Naruto Pairings
RandomSasuSaku? NaruSaku? What about LeeSaku? Of course, then there's SakuHina! What do I think about these ships, and quite a few others? Click here, because I'm not gonna tell ya. (Fanart on cover by multi-saku!)